Ninan Neethu, Thomas Sabu, George Anne, Sebastian Mathew
Centre for Nanoscience & Nanotechnology, Mahatma Gandhi University, Kottayam, Kerala, India.
Ther Deliv. 2011 Jun;2(6):711-5. doi: 10.4155/tde.11.47.
The Institute of Holistic Medical Sciences (IHMS, Kottayam, Kerala, India); the Institute of Macromolecular Science and Engineering (IMSE, Kottayam, Kerala, India) and Mathew Ayurveda und Venen Klinik (MUVK, Klegenfurt, Austria) have jointly conducted a 3-day world conference on Nanomedicine and Drug Delivery (WCN 2011) in Kottayam, Kerala, India from 11-13 March 2011. Application of nanotechnology for treatment, diagnosis, monitoring and control of biological systems has been referred to as 'nanomedicine' by the NIH. Research into the rational delivery and targeting of pharmaceutical, therapeutic, and diagnostic agents is at the forefront of projects in nanomedicine. Nanotechnology will also provide devices to examine tissues in minute detail. Biosensors that are smaller than a cell would give us an inside look at cellular function. Tissues could be analyzed down to the molecular level, giving a completely detailed 'snapshot' of cellular, subcellular, and molecular activities. Today, nanotechnology and nanoscience approaches to particle design and formulation are beginning to expand the market for many drugs and are forming the basis for a highly profitable niche within the industry, but some predicted benefits are hyped. This article gives an outlook of the ongoing research projects conducted all over the world, presented at the conference that highlight rational approaches in design and surface engineering of nanoscale vehicles and entities for site-specific drug delivery and medical imaging after parenteral administration. Potential pitfalls or side effects associated with nanoparticles were also discussed.
印度喀拉拉邦科塔亚姆的整体医学科学研究所(IHMS)、印度喀拉拉邦科塔亚姆的高分子科学与工程研究所(IMSE)以及奥地利克拉根福的马修阿育吠陀与毒液诊所(MUVK)于2011年3月11日至13日在印度喀拉拉邦科塔亚姆联合举办了为期三天的纳米医学与药物递送世界会议(WCN 2011)。美国国立卫生研究院(NIH)将纳米技术在生物系统治疗、诊断、监测和控制方面的应用称为“纳米医学”。对药物、治疗剂和诊断剂的合理递送与靶向研究处于纳米医学项目的前沿。纳米技术还将提供能够详细检查组织的设备。比细胞还小的生物传感器将使我们能够深入了解细胞功能。组织可以被分析到分子水平,从而给出细胞、亚细胞和分子活动的完整详细“快照”。如今,纳米技术和纳米科学在颗粒设计与配方方面的方法正开始扩大许多药物的市场,并为该行业内一个高利润的细分领域奠定基础,但一些预期的好处被夸大了。本文概述了在此次会议上展示的世界各地正在进行的研究项目,这些项目突出了纳米级载体和实体在设计及表面工程方面的合理方法,用于非肠道给药后的定点药物递送和医学成像。还讨论了与纳米颗粒相关的潜在陷阱或副作用。