University College London, Department of Medical Physics and Bioengineering, Gower Street, London WC1E 6BT, United Kingdom.
J Biomed Opt. 2012 Jun;17(6):061202. doi: 10.1117/1.JBO.17.6.061202.
Obtaining absolute chromophore concentrations from photoacoustic images obtained at multiple wavelengths is a nontrivial aspect of photoacoustic imaging but is essential for accurate functional and molecular imaging. This topic, known as quantitative photoacoustic imaging, is reviewed here. The inverse problems involved are described, their nature (nonlinear and ill-posed) is discussed, proposed solution techniques and their limitations are explained, and the remaining unsolved challenges are introduced.
从多波长光声图像中获取绝对色团浓度是光声成象的一个重要方面，但对于准确的功能和分子成象又是必不可少的。本文对这个称为定量光声成象的课题进行了综述。文中叙述了所涉及的反问题，讨论了它们的性质（非线性和不适定），解释了提出的解法技巧及其局限性，并介绍了仍然存在的未解决的难题。
