Huazhong University of Science and Technology, Britton Chance Center for Biomedical Photonics, Wuha National Laboratory for Optoelectronics, Wuhan 430074, China.
J Biomed Opt. 2012 Jun;17(6):066022. doi: 10.1117/1.JBO.17.6.066022.
The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three fold increase in the OCT reflectance from a 300 μm depth and 31% enhancement in image depth Z(threshold).
皮肤组织的强光学散射使得光学相干断层扫描（OCT）很难在皮肤中实现深层成像。通过局部应用光学透明剂 PEG-400、化学增强剂（噻唑或丙二醇）和物理按摩，在 15 分钟内可显著清除体内大鼠皮肤部位的光学散射。只有当所有三种成分一起应用时，15 分钟的治疗才能使来自 300μm 深度的 OCT 反射率增加三倍，并使图像深度 Z（阈值）提高 31%。
