Krupp L B, LaRocca N G, Muir J, Steinberg A D
Department of Neurology, State University of New York, Stony Brook 11794-8121.
J Rheumatol. 1990 Nov;17(11):1450-2.
Fifty-nine patients with systemic lupus erythematosus were evaluated by questionnaires, histories, physical examinations and routine laboratory studies in order to better understand their fatigue. The fatigue severity scale (scored from 1 to 7) was used to measure fatigue and yielded a mean score +/- SD of 4.6 +/- 1.5. Fifty-three percent of the patients reported that fatigue was their most disabling symptom. Although perceived as severe, the symptom of fatigue did not correlate significantly with any of the laboratory measures. However, there was a significant correlation between fatigue and the physician's rating of disease activity. Fatigue also correlated significantly with depression which accounted for 21% of the variation in fatigue scores.
为了更好地了解系统性红斑狼疮患者的疲劳情况，对59例此类患者进行了问卷调查、病史询问、体格检查及常规实验室检查。采用疲劳严重程度量表（评分从1至7）来测量疲劳程度，得出的平均得分±标准差为4.6±1.5。53%的患者报告称疲劳是最使他们丧失活动能力的症状。尽管疲劳症状被认为很严重，但它与任何实验室指标均无显著相关性。然而，疲劳与医生对疾病活动度的评分之间存在显著相关性。疲劳与抑郁也显著相关，抑郁占疲劳评分变化的21%。
