Tokiyama K, Yokota E, Niho Y
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Rheumatol. 1990 Nov;17(11):1463-8.
Epidermal growth factor receptor (EGF-R) of fibroblasts from 3 patients with scleroderma (progressive systemic sclerosis, PSS) was studied by radioiodinated-EGF binding assay. The binding was 60.9 +/- 4.0% of normal fibroblasts, and the Scatchard plots showed a decrease in the affinity for EGF, not in the number of EGF-R. PSS fibroblasts expressed higher levels (1.15-2.45-fold) of RNA for the v-erbB (EGF-R gene). All-transretinoic acid (retinoid) had little effect on EGF-R, v-erbB gene expression and the proliferation of PSS fibroblasts. These data concerning the abnormality in the EGF-R may all constitute a feature of PSS fibroblasts.
采用放射性碘标记的表皮生长因子（EGF）结合试验，对3例硬皮病（进行性系统性硬化症，PSS）患者成纤维细胞的表皮生长因子受体（EGF-R）进行了研究。其结合量为正常成纤维细胞的60.9±4.0%，Scatchard图显示对EGF的亲和力降低，而非EGF-R数量减少。PSS成纤维细胞中v-erbB（EGF-R基因）的RNA表达水平较高（1.15 - 2.45倍）。全反式维甲酸（类维生素A）对PSS成纤维细胞的EGF-R、v-erbB基因表达及增殖影响很小。这些关于EGF-R异常的数据可能均构成PSS成纤维细胞的一个特征。
