State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
Fitoterapia. 2012 Oct;83(7):1275-80. doi: 10.1016/j.fitote.2012.06.005. Epub 2012 Jun 23.
Two new isocoumarins (1 and 2), a new alkaloid (3), and a known N-acetyldopamine dimer (4) were isolated from the ethyl acetate extract of Chinese insect medicine Eupolyphaga sinensis. Their structures were elucidated on the basis of detailed spectroscopic investigations, such as 1D- and 2D NMR spectroscopy, as well as by means of HR-MS. The structure of 1 was firmly confirmed by X-ray crystallography, and the absolute configuration was revealed by experimental and computational optical rotation analyses. Cytotoxicities of 1-4 were measured in vitro against 10 selected cancer cell lines.
从中国药用昆虫土元的乙酸乙酯提取物中分离得到两个新的异香豆素（1 和 2）、一个新的生物碱（3）和一个已知的 N-乙酰多巴胺二聚体（4）。基于详细的光谱研究，如 1D 和 2D NMR 光谱以及高分辨率质谱（HR-MS），确定了它们的结构。通过 X 射线晶体学确定了 1 的结构，并通过实验和计算旋光分析揭示了其绝对构型。在体外对 10 种选定的癌细胞系测定了 1-4 的细胞毒性。
