State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Phytochemistry. 2012 Feb;74:140-5. doi: 10.1016/j.phytochem.2011.11.002. Epub 2011 Nov 25.
Four vobasinyl-ibogan type bisindole alkaloids, ervachinines A-D (1-4), along with 12 known terpenoid indole alkaloids, were isolated from the whole plant of Ervatamia chinensis. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR, and the absolute configurations of 1-4 were determined by CD exciton chirality method. All of the compounds were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Bisindole alkaloids 1-6 exhibited inhibitory effects, with IC(50) values comparable to those of cisplatin.
从中国白前全草中分离得到了 4 个 vobasinyl-ibogan 型双吲哚生物碱，即 ervachinines A-D（1-4），以及 12 个已知的萜类吲哚生物碱。通过分析包括 1D 和 2D NMR 在内的光谱数据阐明了它们的结构，并通过 CD 激子手性法确定了 1-4 的绝对构型。所有化合物均对五种人癌细胞系（HL-60、SMMC-7721、A-549、MCF-7 和 SW480）进行了体外细胞毒性评估。双吲哚生物碱 1-6 表现出抑制作用，其 IC50 值与顺铂相当。
