人类、猴子和狗对 N-甲基化儿茶酚胺的脑血管反应性。

Cerebrovascular reactivities to N-methylated catecholamines in humans, monkeys and dogs.

作者信息

Usui H, Shirahase H, Kurahashi K

机构信息

Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.

出版信息

Jpn J Pharmacol. 1990 Sep;54(1):89-92. doi: 10.1254/jjp.54.89.

DOI:10.1254/jjp.54.89

PMID:2273653

Abstract

A comparison was made of the cerebrovascular responses of humans, monkeys and dogs to noradrenaline (NAd) and dopamine (DA) as well as to their N-methylated derivatives, adrenaline (Ad) and N-methyl dopamine (methyl DA). The present experiments demonstrated that N-methylation of both NAd and DA enhanced the contractile responses of these agents in human cerebral arteries, while only N-methylation of DA enhanced the contraction of monkey cerebral arteries, and such an enhancement was not seen in dog cerebral arteries.

摘要

对人类、猴子和狗的脑血管对去甲肾上腺素（NAd）、多巴胺（DA）及其N-甲基化衍生物肾上腺素（Ad）和N-甲基多巴胺（甲基DA）的反应进行了比较。目前的实验表明，NAd和DA的N-甲基化均增强了这些药物对人脑动脉的收缩反应，而只有DA的N-甲基化增强了猴脑动脉的收缩，在狗脑动脉中未观察到这种增强。