Department of Immunobiology, The University of Arizona College of Medicine Tucson, AZ, USA.
Front Immunol. 2012 Jun 25;3:159. doi: 10.3389/fimmu.2012.00159. eCollection 2012.
"How does T cell receptor signaling begin?" Answering this question requires an understanding of how the parts of the molecular machinery that mediates this process fit and work together. Ultimately this molecular architecture must (i) trigger the relay of information from the TCR-pMHC interface to the signaling substrates of the CD3 molecules and (ii) bring the kinases that modify these substrates in close proximity to interact, initiate, and sustain signaling. In this contribution we will discuss advances of the last decade that have increased our understanding of the complex machinery and interactions that underlie this type of signaling.
“T 细胞受体信号转导是如何开始的？”要回答这个问题，需要了解介导这一过程的分子机制的各个部分如何适配和协同工作。最终，这种分子结构必须 (i) 触发 TCR-pMHC 界面的信息传递到 CD3 分子的信号底物，(ii) 使修饰这些底物的激酶紧密靠近以相互作用、启动和维持信号转导。在本贡献中，我们将讨论过去十年的进展，这些进展增加了我们对这种信号转导所依赖的复杂机制和相互作用的理解。
