Applied Molecular Hepatology Laboratory, Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University Hospital Leipzig Leipzig, Germany.
Front Immunol. 2012 Jun 22;3:168. doi: 10.3389/fimmu.2012.00168. eCollection 2012.
Mesenchymal stem cells represent an alternate cell source to substitute for primary hepatocytes in hepatocyte transplantation because of their multiple differentiation potential and nearly unlimited availability. They may differentiate into hepatocyte-like cells in vitro and maintain specific hepatocyte functions also after transplantation into the regenerating livers of mice or rats both under injury and non-injury conditions. Depending on the underlying liver disease their mode of action is either to replace the diseased liver tissue or to support liver regeneration through their anti-inflammatory and anti-apoptotic as well as their pro-proliferative action.
间充质干细胞因其多向分化潜能和近乎无限的可用性，成为肝细胞移植替代原代肝细胞的另一种细胞来源。它们在体外可分化为肝样细胞，并且在移植到损伤和非损伤条件下的小鼠或大鼠再生肝脏后，也能维持特定的肝细胞功能。根据潜在的肝脏疾病，其作用模式要么是替代病变的肝组织，要么是通过抗炎、抗细胞凋亡和促进增殖作用来支持肝再生。
