Lu Paul Cs, Chen Jackie Cl
Buddhist Tzu Chi General Hospital, Taipei, Taiwan.
J Ophthalmic Vis Res. 2010 Apr;5(2):75-81.
To investigate whether seasonal modification in the concentration of atropine drops is effective in retarding the progression of myopia.
Two hundred and forty eyes of 120 healthy preschool- and school-age children in Chiayi region, Taiwan were recruited. The treatment group consisted of 126 eyes of 63 children who received atropine eye drops daily for one year and the control group included 114 eyes of 57 children who received nothing. The concentration of atropine eye drops was modified by seasonal variation as follows: 0.1% for summer, 0.25% for spring and fall, and 0.5% for winter. Refractive error, visual acuity, intraocular pressure (IOP), and axial length were evaluated before and after intervention.
Mean age was 9.1±2.8 years in the atropine group versus 9.3±2.8 years in controls (P=0.88). Mean spherical equivalent, refractive error and astigmatism were -1.90±1.66 diopters (D) and -0.50±0.59 D in the atropine group; corresponding values in the control group were -2.09±1.67 D (P=0.97) and -0.55±0.60 D (P=0.85), respectively. After one year, mean progression of myopia was 0.28±0.75 D in the atropine group vs 1.23±0.44 D in controls (P<0.001). Myopic progression was significantly correlated with an increase in axial length in both atropine (r=0.297, P=0.001) and control (r=0.348, P<0.001) groups. No correlation was observed between myopic progression and IOP in either study group.
Modifying the concentration of atropine drops based on seasonal variation, seems to be effective and tolerable for retarding myopic progression in preschool- to school-age children.
探讨根据季节调整阿托品滴眼液浓度是否能有效延缓近视进展。
招募了台湾嘉义地区120名健康学龄前及学龄儿童的240只眼睛。治疗组由63名儿童的126只眼睛组成，他们每天使用阿托品滴眼液，持续一年；对照组包括57名儿童的114只眼睛，未接受任何治疗。阿托品滴眼液的浓度根据季节变化进行调整，如下：夏季为0.1%，春秋季为0.25%，冬季为0.5%。在干预前后评估屈光不正、视力、眼压（IOP）和眼轴长度。
阿托品组的平均年龄为9.1±2.8岁，对照组为9.3±2.8岁（P=0.88）。阿托品组的平均等效球镜、屈光不正和散光分别为-1.90±1.66屈光度（D）和-0.50±0.59 D；对照组的相应值分别为-2.09±1.67 D（P=0.97）和-0.55±0.60 D（P=0.85）。一年后，阿托品组近视的平均进展为0.28±0.75 D，对照组为1.23±0.44 D（P<0.001）。在阿托品组（r=0.297，P=0.001）和对照组（r=0.348，P<0.001）中，近视进展均与眼轴长度的增加显著相关。在两个研究组中，均未观察到近视进展与眼压之间的相关性。
根据季节变化调整阿托品滴眼液的浓度，对于延缓学龄前至学龄儿童的近视进展似乎是有效且可耐受的。
