鸦片成瘾是骨质流失的一个风险因素吗？
Is opium addiction a risk factor for bone loss?
作者信息
Gozashti M H, Shahesmaeili A, Amini Zadeh N
机构信息
Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
出版信息
Iran Red Crescent Med J. 2011 Jul;13(7):464-8. Epub 2011 Jul 1.
BACKGROUND
Drug abuse is one of the most important public health problems worldwide as in Iran. The aim of present study was to determine whether opium addiction can affect bone mineral density or not.
METHODS
Fifty opium addicted and 50 non-addicted volunteer men aged between 25-45 were enrolled. The subjects with positive history of other osteoporosis risk factors were excluded. The vertebral bone density and potential confounders (age, cigarette smoking and body mass index) were measured in all subjects.
RESULTS
Twenty six percent of non-addicted vs. 56% of addicted subjects had vertebral osteopenia. According to adjusted ORs, addiction to opium (OR: 3.08, CI95% 1.20-7.92) and age (OR: 1.11 CI95% 1.03-1.20) were significantly related to vertebral bone loss.
CONCLUSION
Opium addicted patients were more susceptible to bone loss than non-addicted individuals. So,early screening and conducting prevention programs should be taken into consideration for this high risk group.
背景
药物滥用是全球以及伊朗最重要的公共卫生问题之一。本研究的目的是确定鸦片成瘾是否会影响骨矿物质密度。
方法
招募了50名年龄在25至45岁之间的鸦片成瘾男性志愿者和50名非成瘾男性志愿者。排除有其他骨质疏松风险因素阳性病史的受试者。测量了所有受试者的椎骨密度和潜在混杂因素（年龄、吸烟和体重指数）。
结果
26%的非成瘾受试者与56%的成瘾受试者患有椎体骨质减少。根据校正后的比值比，鸦片成瘾（比值比：3.08，95%置信区间1.20 - 7.92）和年龄（比值比：1.11，95%置信区间1.03 - 1.20）与椎体骨质流失显著相关。
结论
鸦片成瘾患者比非成瘾个体更容易发生骨质流失。因此，对于这个高危群体，应考虑进行早期筛查并开展预防项目。
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