Heydari Zeynab, Shahesmaeili Armita, Khajeh-Bahrami Mohammad Reza, Rezazadeh-Mehrizi Mandana, Gozashti Mohammad Hossein, Moazed Vahid
Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Assistant Professor, HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
Addict Health. 2017 Fall;9(4):214-221.
Osteoporosis and osteopenia are the most common metabolic bone diseases making the patients vulnerable to bone fragility and fracture. In this study, the association of opium consumption and osteoporosis adjusted for other risk factors was studied.
In this cross-sectional study, 619 cases including 73 men and 546 women referred to densitometry center in Kerman, Iran, were studied. Demographic information, history of opium consumption, medications, and other risk factors were collected using a structured questionnaire.
In a univariate analysis, opium consumption, aging, and having a body mass index (BMI) lower than 24 accompanied an increased chance of osteoporosis, while taking physical exercises on a daily basis reduces the chance of osteoporosis. Through multivariable analysis, the two variables of age group and BMI group turned out to be of significance; that is, the chance of osteoporosis or osteopenia in the age group of higher than 60 years and 45-60 years being placed in one of the levels of osteoporosis or osteopenia was 4.9 and 3.1 times higher than the age groups lower than 45 years, respectively, after being adjusted to the other variables.
Considering the results of this study, though the risk of bone density reduction in the individuals consuming opium was higher, due to the disparity between opium consumption in the two sexes, the difference was not significant between the two groups, and it is proposed that studies on larger samples and in the both sexes be conducted to determine the impacts of opium on the bone density.
骨质疏松症和骨质减少是最常见的代谢性骨病，会使患者易发生骨脆性和骨折。在本研究中，我们研究了在调整其他风险因素后鸦片消费与骨质疏松症之间的关联。
在这项横断面研究中，我们对619例患者进行了研究，其中包括73名男性和546名女性，这些患者均前往伊朗克尔曼的骨密度检测中心就诊。我们使用结构化问卷收集了人口统计学信息、鸦片消费史、用药情况及其他风险因素。
在单因素分析中，鸦片消费、年龄增长以及体重指数（BMI）低于24与骨质疏松症发生几率增加相关，而每天进行体育锻炼则会降低患骨质疏松症的几率。通过多变量分析，年龄组和BMI组这两个变量具有显著意义；也就是说，在调整其他变量后，60岁以上年龄组和45 - 60岁年龄组处于骨质疏松症或骨质减少症某一水平的骨质疏松症或骨质减少症发生几率分别比45岁以下年龄组高4.9倍和3.1倍。
考虑到本研究的结果，尽管吸食鸦片者骨密度降低的风险较高，但由于两性之间鸦片消费量存在差异，两组之间的差异并不显著，建议对更大样本且涵盖两性的研究进行开展，以确定鸦片对骨密度的影响。
