Fowler Robin M, Gain Kevin R, Gabbay Eli
Advanced Lung Disease Program, Royal Perth Hospital, Level 3 Ainslie House, Murray Street, Western Australia 6000, GPO Box 2213, Perth, WA 6847, Australia.
Pulm Med. 2012;2012:359204. doi: 10.1155/2012/359204. Epub 2012 Jun 10.
Pulmonary arterial hypertension (PAH) is associated with symptoms of dyspnea and fatigue, which contribute to exercise limitation. The origins and significance of dyspnea and fatigue in PAH are not completely understood. This has created uncertainly among healthcare professionals regarding acceptable levels of these symptoms, on exertion, for patients with PAH. Dysfunction of the right ventricle (RV) contributes to functional limitation and mortality in PAH; however, the role of the RV in eliciting dyspnea and fatigue has not been thoroughly examined. This paper explores the contribution of the RV and systemic and peripheral abnormalities to exercise limitation and symptoms in PAH. Further, it explores the relationship between exercise abnormalities and symptoms, the utility of the cardiopulmonary exercise test in identifying RV dysfunction, and offers suggestions for further research.
肺动脉高压（PAH）与呼吸困难和疲劳症状相关，这些症状会导致运动受限。PAH中呼吸困难和疲劳的起源及意义尚未完全明确。这使得医疗保健专业人员对于PAH患者在运动时这些症状的可接受程度存在不确定性。右心室（RV）功能障碍会导致PAH患者出现功能受限和死亡；然而，RV在引发呼吸困难和疲劳方面的作用尚未得到充分研究。本文探讨了RV以及全身和外周异常对PAH患者运动受限和症状的影响。此外，还探讨了运动异常与症状之间的关系、心肺运动试验在识别RV功能障碍方面的效用，并为进一步研究提供了建议。
