Gezgen G, Roach E C, Kizilarslanoglu M C, Petekkaya I, Altundag K
Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey.
J BUON. 2012 Apr-Jun;17(2):223-9.
Worldwide, breast cancer is the most frequently diagnosed life-threatening cancer in women and the most important cause of cancer-related deaths among women. This disease is on the rise in Turkey. Metabolic syndrome is a cluster of metabolic disturbances including insulin resistance, dyslipidemia, hypertension, abdominal obesity and high blood sugar. Several studies have examined the association of the individual components of the metabolic syndrome with breast cancer. More recent studies have shown it to be an independent risk factor for breast cancer. It has also been associated with poorer prognosis, increased incidence, a more aggressive tumor phenotype. Basic research studies are now in progress to illuminate the molecular pathways and mechanisms that are behind this correlation. Given the fact that all of the components of metabolic syndrome are modifiable risk factors, preventive measures must be established to improve the outcome of breast cancer patients. In this review we set the background by taking into account previous studies which have identified the components of metabolic syndrome individually as breast cancer risk factors. Then we present the latest findings which elaborate possible explanations regarding how metabolic syndrome as a single entity may affect breast cancer risk.
在全球范围内，乳腺癌是女性中最常被诊断出的危及生命的癌症，也是女性癌症相关死亡的最重要原因。这种疾病在土耳其呈上升趋势。代谢综合征是一组代谢紊乱，包括胰岛素抵抗、血脂异常、高血压、腹部肥胖和高血糖。多项研究探讨了代谢综合征的各个组成部分与乳腺癌之间的关联。最近的研究表明，它是乳腺癌的一个独立危险因素。它还与较差的预后、发病率增加、更具侵袭性的肿瘤表型有关。目前正在进行基础研究，以阐明这种关联背后的分子途径和机制。鉴于代谢综合征的所有组成部分都是可改变的危险因素，必须制定预防措施以改善乳腺癌患者的治疗结果。在这篇综述中，我们通过考虑以前将代谢综合征的各个组成部分单独确定为乳腺癌危险因素的研究来奠定背景。然后我们展示了最新的研究结果，这些结果详细阐述了代谢综合征作为一个整体可能如何影响乳腺癌风险的可能解释。
