Department of Otolaryngology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.
J Surg Oncol. 2012 Dec;106(8):942-6. doi: 10.1002/jso.23202. Epub 2012 Jun 27.
This study evaluated the relationships between capsular characteristics and recurrence of parotid pleomorphic adenomas.
The pathological slides and clinical data of 110 patients that underwent superficial parotidectomy for pleomorphic adenoma in the parotid gland were reviewed retrospectively. The recurrent and non-recurrent groups comprised 10 and 100 patients, respectively. The two groups were compared with regard to their clinicopathological features, including the capsular characteristics.
Satellite nodules were observed in six of the 10 recurrent group patients (60.0%) but in only 10 of the 100 non-recurrent group patients (10.0%) (P = 0.001). Five of the recurrent group subjects (50%), but only 11 of the 100 non-recurrent group subjects (11.0%), had positive resection margins (P = 0.006). Perioperative rupture of the tumor was observed in three recurrent group subjects (30%), but in only four of the non-recurrent group subjects (4.0%) (P = 0.016). Multivariate analyses showed that the risk of recurrence was more than fivefold higher when satellite nodules were present (P = 0.010) and more than 14-fold higher when the tumor had ruptured (P = 0.001).
Satellite nodules and tumor rupture increase the risk of recurrence in patients with pleomorphic adenomas treated by superficial parotidectomy.
本研究评估了包膜特征与腮腺多形性腺瘤复发之间的关系。
回顾性分析了 110 例因腮腺多形性腺瘤行腮腺浅叶切除术患者的病理切片和临床资料。复发组和未复发组分别包括 10 例和 100 例患者。比较了两组的临床病理特征，包括包膜特征。
复发组的 10 例患者中有 6 例（60.0%）出现卫星结节，而非复发组的 100 例患者中有 10 例（10.0%）（P = 0.001）。复发组的 5 例患者（50%）有阳性切缘，而非复发组的 11 例患者（11.0%）（P = 0.006）。复发组的 3 例患者（30%）有肿瘤围手术期破裂，而非复发组的 4 例患者（4.0%）（P = 0.016）。多变量分析显示，存在卫星结节时复发风险增加超过 5 倍（P = 0.010），肿瘤破裂时复发风险增加超过 14 倍（P = 0.001）。
卫星结节和肿瘤破裂增加了接受腮腺浅叶切除术治疗的多形性腺瘤患者的复发风险。
