萜品油烯是药鼠尾草的一种成分，可下调K562细胞中AKT1的表达。
Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells.
作者信息
Okumura Naoko, Yoshida Hitomi, Nishimura Yuri, Kitagishi Yasuko, Matsuda Satoru
机构信息
Department of Environmental Health Science, Nara Women's University, Nara 630-8506, Japan.
出版信息
Oncol Lett. 2012 Feb;3(2):321-324. doi: 10.3892/ol.2011.491. Epub 2011 Nov 18.
Abstract
Protein kinase AKT mediates cell proliferation and survival signals, and also contributes to cancer progression. Increased expression and/or activation of AKT is involved in a variety of human cancers. In cells treated with sage or rosemary extract, mRNA and protein expression levels of AKT1 were reduced compared with those of the control cells 48 h after the herbal treatments. We found that terpinolene, a common component of sage and rosemary, markedly reduced the protein expression of AKT1 in K562 cells and inhibited cell proliferation.
摘要
蛋白激酶AKT介导细胞增殖和存活信号，也促进癌症进展。AKT表达增加和/或激活与多种人类癌症有关。在用鼠尾草或迷迭香提取物处理的细胞中，草药处理48小时后，与对照细胞相比，AKT1的mRNA和蛋白表达水平降低。我们发现，萜品油烯是鼠尾草和迷迭香的常见成分，可显著降低K562细胞中AKT1的蛋白表达并抑制细胞增殖。
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