Department of Pharmacology, Faculty of Pharmacy, University Complutense, Ciudad Universitaria s/n, 28040, Madrid, Spain.
Curr Drug Metab. 2010 Feb;11(2):171-81. doi: 10.2174/138920010791110818.
Medicinal plants are gaining in popularity due to the various advantages they offer, such as fewer side-effects, better patient compliance, relatively low cost and high accessibility as well as their high acceptability due to a long history of use. There is a widespread belief among the general public that herbal preparations are "good for humans" as they are "all natural". However, the increasing use of herbal medicinal products in the community where people are also receiving prescription medicines suggests that adverse herb-drug interactions may be have significant public health consequences. There is little understanding or appreciation of the fact that these "all natural" preparations are actually a combination of potentially biologically active compounds already existing in marketed products in unknown quantities. Among the most popular herbal products used worldwide is Ginkgo biloba, used for the treatment of cerebral insufficiency, peripheral vascular diseases, and frequently taken for the enhancement of memory function. Although the safety of Ginkgo biloba is promising, accumulated data show evidence of significant interactions with medications, which can place individual patients at great risk. In this review, we examined the literature from 2000 to 2008 and focused on the importance of the risk of drug interactions and potential side effects when Ginkgo biloba is involved. The aim of this systematic review is to assess the clinical evidence on interactions between Ginkgo biloba and drugs.
由于药用植物具有较少的副作用、更好的患者依从性、相对较低的成本和较高的可及性以及由于长期使用而具有较高的可接受性等各种优势，它们越来越受到欢迎。公众普遍认为草药制剂“对人类有益”，因为它们是“纯天然的”。然而，社区中越来越多地使用草药药物，同时人们也在服用处方药，这表明草药-药物相互作用可能会产生重大的公共健康后果。人们很少理解或认识到这些“纯天然”制剂实际上是已经存在于市售产品中的潜在生物活性化合物的组合，其数量未知。在全球范围内使用最广泛的草药产品之一是银杏，用于治疗脑功能不全、周围血管疾病，并且经常用于增强记忆功能。尽管银杏的安全性很有希望，但积累的数据表明它与药物之间存在显著的相互作用，这可能使个别患者面临巨大风险。在这篇综述中，我们检查了 2000 年至 2008 年的文献，并重点关注了银杏涉及药物相互作用和潜在副作用的风险。本系统评价的目的是评估银杏与药物之间相互作用的临床证据。
