Visnyei Koppany, Shahrokni Armin, Hashmi Shahrukh, Orell Jeffrey, Wild Dorothea M G
Department of Medicine, Griffin Hospital, Yale School of Medicine, Derby, CT.
Oncol Lett. 2012 Feb;3(2):335-337. doi: 10.3892/ol.2011.475. Epub 2011 Nov 8.
Humoral hypercalcemia of malignancy is frequently observed in patients with solid tumors. However, few instances have been described involving patients with gynecological malignancies. We report a case of endometrioid carcinoma of the uterine corpus in a patient who initially presented with hypercalcemia. The elevated calcium levels were found to be the result of an increased serum concentration of parathyroid hormone-related peptide (PTHrP). PTHrP is commonly secreted by malignant cells and suppresses PTH. This case demonstrates that endometrial cancer should be considered in the differential diagnosis of patients presenting with symptomatic or asymptomatic hypercalcemia.
恶性肿瘤相关性体液性高钙血症在实体瘤患者中较为常见。然而，涉及妇科恶性肿瘤患者的此类病例报道较少。我们报告一例子宫体子宫内膜样癌患者，该患者最初表现为高钙血症。发现血钙水平升高是甲状旁腺激素相关肽（PTHrP）血清浓度升高所致。PTHrP通常由恶性细胞分泌并抑制甲状旁腺激素（PTH）。该病例表明，对于出现有症状或无症状高钙血症的患者，鉴别诊断时应考虑子宫内膜癌。
