Richey Daniel S, Welch Brian J
Department of Internal Medicine, Baylor University Medical Center, Dallas, TX 75246, USA.
South Med J. 2008 Dec;101(12):1266-8. doi: 10.1097/SMJ.0b013e318181d59d.
A 65-year-old Caucasian woman with a known history of clear cell endometrial cancer presented with hypercalcemia. Further evaluation demonstrated that the patient had primary hyperparathyroidism due to a parathyroid adenoma, as well as an increased parathyroid hormone-related peptide secondary to her malignancy. To the best of our knowledge, this is the first reported case of a female patient with concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy. This case illustrates the importance of considering a broad differential when evaluating patients with hypercalcemia. It also emphasizes the importance of recognizing the biochemical interplay between parathyroid hormone and parathyroid hormone-related peptide.
一名65岁的白人女性，有透明细胞子宫内膜癌病史，出现高钙血症。进一步评估显示，该患者因甲状旁腺腺瘤患有原发性甲状旁腺功能亢进，同时因恶性肿瘤导致甲状旁腺激素相关肽增加。据我们所知，这是首例报告的同时患有原发性甲状旁腺功能亢进和恶性肿瘤体液性高钙血症的女性患者。该病例说明了在评估高钙血症患者时考虑广泛鉴别诊断的重要性。它还强调了认识甲状旁腺激素和甲状旁腺激素相关肽之间生化相互作用的重要性。
