人参皂苷对大鼠骨髓中DNA、蛋白质和脂质合成的刺激作用及环核苷酸的参与

Stimulatory effect of ginsenosides on DNA, protein and lipid synthesis in rat bone marrow and participation of cyclic nucleotides.

作者信息

Yamamoto M, Masaka M, Yamada K, Hayashi Y, Hirai A, Kumagai A

出版信息

Arzneimittelforschung. 1978;28(12):2238-41.

Abstract

Effects of several kinds of ginsenosides, saponins from Panax ginseng on DNA, RNA, protein and lipid synthesis in bone marrow were investigated. Single i.p. injection of 0.5--1 mg/100 g body weight of ginsenosides Rb2, Rc, Re and Rg1 4 h prior to the sacrifice increased DNA synthesis in bone marrow cells. RNA, protein and lipid synthesis were also increased. The direct addition of ginsenosides Rb1, Rb2 and Rc mixture (GNS) enhanced DNA synthesis. Cyclic AMP levels in bone marrow cells were decreased 20 min after i.p. injection of ginsenosides Rb2, Rc and Rg1 and the direct addition of ginsenosides Rb2, Rc and Rg1 also decreased cyclic AMP levels. While cyclic GMP levels were increased by administration of ginsenosides Rb2, Re and Rg1. Relationship between chemical structure and actions of ginsenosides and the role of cyclic nucleotides in the stimulatory action of ginsenosides on DNA synthesis in bone marrow cells were discussed.

摘要

研究了几种人参皂苷（人参中的皂苷）对骨髓中DNA、RNA、蛋白质和脂质合成的影响。在处死前4小时，以0.5 - 1毫克/100克体重的剂量腹腔注射人参皂苷Rb2、Rc、Re和Rg1，可增加骨髓细胞中的DNA合成。RNA、蛋白质和脂质合成也增加。直接添加人参皂苷Rb1、Rb2和Rc混合物（GNS）可增强DNA合成。腹腔注射人参皂苷Rb2、Rc和Rg1 20分钟后，骨髓细胞中的环磷酸腺苷（cAMP）水平降低，直接添加人参皂苷Rb2、Rc和Rg1也会降低cAMP水平。而人参皂苷Rb2、Re和Rg1的给药会增加环磷酸鸟苷（cGMP）水平。讨论了人参皂苷的化学结构与作用之间的关系以及环核苷酸在人参皂苷对骨髓细胞DNA合成的刺激作用中的作用。