Department of Dermatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55605, USA.
Dermatol Ther. 2012 Mar-Apr;25(2):183-94. doi: 10.1111/j.1529-8019.2012.01490.x.
Livedoid vasculopathy (LV) is characterized by painful purple macules and papules that subsequently ulcerate. The lesions heal over weeks to months resulting in smooth, porcelain-white, atrophic plaque-like areas with surrounding telangiectases and hyperpigmentation. The specific cause of LV is still to be determined and it is believed to be multifactorial in nature. Despite numerous available therapeutic agents, there is not a single best efficacious treatment for LV. Most of the available treatment options are based on isolated case reports or case series. In this article, studies on the pathogenesis and therapeutic approaches to LV are reviewed.
皮肤白细胞破碎性血管炎（LV）的特征是疼痛性紫色斑疹和丘疹，随后溃疡。病变在数周至数月内愈合，导致光滑、瓷白色、萎缩性斑块样区域，伴有周围毛细血管扩张和色素沉着。LV 的具体病因仍有待确定，据信其性质是多因素的。尽管有许多可用的治疗药物，但对于 LV 并没有单一的最佳有效治疗方法。大多数可用的治疗选择基于孤立的病例报告或病例系列。本文回顾了 LV 的发病机制和治疗方法的研究。
