Kavala Mukaddes, Kocaturk Emek, Zindanci Ilkin, Turkoglu Zafer, Altintas Sumeyye
Goztepe Training and Research Hospital, Department of Dermatology, Istanbul, Turkey.
J Dermatolog Treat. 2008;19(2):121-3. doi: 10.1080/09546630701670305.
Livedoid vasculopathy is characterized by painful purpuric lesions on the extremities which frequently ulcerate and heal with atrophic scarring. It has been considered to be a vasculitic process but now there has been increasing evidence that abnormal coagulation plays a major role in the pathogenesis of this rare disorder. We report the case of a 19-year-old male who had been suffering from recurrent painful ulcerations on both lower legs with atrophic scars for 4 years. A biopsy specimen revealed vasculopathy, and laboratory studies showed resistance to activated protein C with factor V Leiden mutation. Treatment with oral warfarin led to rapid improvement of the lesions.
