Allnatt J P, Dickson K E, Lisney S J
Department of Physiology, School of Medical Sciences, Bristol, U.K.
Neurosci Lett. 1990 Oct 16;118(2):219-22. doi: 10.1016/0304-3940(90)90631-i.
Leakage of Evans blue dye from the circulation into the skin has been used to measure plasma extravasation evoked by antidromic nerve stimulation of the saphenous nerves in anaesthetised rats. Normal animals and ones in which one saphenous nerve had been cut and left to regenerate some time before were studied. Saphenous nerve injury on one side of a rat significantly reduced the ability of the contralateral, uninjured nerve to evoke plasma extravasation compared with the response measured in totally uninjured control animals. This suppression of plasma extravasation was not dependent on activation of nerve fibres in the regenerated nerve. The effect was evident by 6 weeks after injury and persisted for at least another 20 weeks. At the moment the mechanism underlying this suppression of neurogenic plasma extravasation is unknown.
伊文思蓝染料从循环系统漏入皮肤，已被用于测量麻醉大鼠隐神经逆行神经刺激诱发的血浆外渗。研究了正常动物以及一侧隐神经被切断并在一段时间前任其再生的动物。与完全未受伤的对照动物相比，大鼠一侧的隐神经损伤显著降低了对侧未受伤神经诱发血浆外渗的能力。这种血浆外渗的抑制并不依赖于再生神经中神经纤维的激活。损伤后6周效应明显，并至少持续另外20周。目前，这种神经源性血浆外渗抑制的潜在机制尚不清楚。
