Wiesenfeld-Hallin Z, Kinnman E, Aldskogius H
Department of Clinical Physiology and Neurophysiology, Karolinska Institute, Huddinge University Hospital, Sweden.
Agents Actions. 1988 Dec;25(3-4):260-2. doi: 10.1007/BF01965028.
Two sets of experiments were carried out in order to evaluate the unmyelinated (C) fibre innervation of the hindlimb of rats. In the first experiment the normal innervation territory of the various nerves to the skin in the hindfoot was examined by plasma extravasation of Evans blue after antidromic nerve stimulation. Considerable overlap was found in the territories of nerves on the dorsum of the toes and just proximal to the toes. In the second experiment the capacity of C-fibres in the saphenous nerve for growth into deafferented skin was examined. In rats in which the sciatic nerve was previously sectioned, the innervation territory of the intact saphenous nerve expanded slightly into that of the sciatic in about 20% of the cases by "collateral sprouting". When the sciatic nerve section was combined with ipsilateral saphenous nerve crush, the regenerating C-fibres in the saphenous nerve innervated the sciatic territory in almost 100% of cases, a process we termed "expansive regenerative reinnervation". We conclude that the existence of overlapping C-fibre innervation territories need to be considered in studies of "collateral sprouting". However, regenerating C-fibres can innervate foreign deafferented skin.
为了评估大鼠后肢无髓鞘（C）纤维的神经支配情况，进行了两组实验。在第一个实验中，通过逆行神经刺激后伊文思蓝的血浆外渗来检查后足皮肤各神经的正常神经支配区域。在脚趾背侧和刚好在脚趾近端的神经区域发现了相当大的重叠。在第二个实验中，检查了隐神经中C纤维向去传入神经皮肤生长的能力。在先前切断坐骨神经的大鼠中，完整隐神经的神经支配区域在约20%的情况下通过“侧支发芽”略微扩展到坐骨神经的支配区域。当坐骨神经切断与同侧隐神经挤压相结合时，隐神经中再生的C纤维在几乎100%的情况下支配坐骨神经区域，这一过程我们称为“扩展性再生再支配”。我们得出结论，在“侧支发芽”研究中需要考虑重叠的C纤维神经支配区域的存在。然而，再生的C纤维可以支配外来的去传入神经皮肤。
