HIV 中的可溶性炎症介质及其对治疗和疫苗开发的意义。
Soluble mediators of inflammation in HIV and their implications for therapeutics and vaccine development.
机构信息
Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA.
出版信息
Cytokine Growth Factor Rev. 2012 Aug-Oct;23(4-5):193-206. doi: 10.1016/j.cytogfr.2012.05.006. Epub 2012 Jun 27.
Abstract
From early in the HIV epidemic it was appreciated that many inflammatory markers such as neopterin and TNF-α were elevated in patients with AIDS. With the advent of modern technology able to measure a broad array of cytokines, we now know that from the earliest points of infection HIV induces a cytokine storm. This review will focus on how cytokines are disturbed in HIV infection and will explore potential therapeutic uses of cytokines. These factors can be used directly as therapy during HIV infection, either to suppress viral replication or prevent deleterious immune effects of infection, such as CD4+ T cell depletion. Cytokines also show great promise as adjuvants in the development of HIV vaccines, which would be critical for the eventual control of the epidemic.
摘要
从艾滋病流行早期开始，人们就意识到许多炎症标志物，如犬尿酸和 TNF-α，在艾滋病患者中升高。随着现代技术能够测量广泛的细胞因子，我们现在知道，从感染的最初阶段，HIV 就会引发细胞因子风暴。这篇综述将重点讨论细胞因子在 HIV 感染中是如何失调的，并探讨细胞因子的潜在治疗用途。这些因子可在 HIV 感染期间直接用作治疗，以抑制病毒复制或防止感染的有害免疫效应，如 CD4+T 细胞耗竭。细胞因子在 HIV 疫苗的开发中也具有很大的应用前景，这对于最终控制艾滋病的流行至关重要。
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