Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cytokine Growth Factor Rev. 2012 Aug-Oct;23(4-5):181-91. doi: 10.1016/j.cytogfr.2012.05.005. Epub 2012 Jun 27.
Numerous studies have characterized the cytokine modulation observed in human immunodeficiency virus (HIV) infected individuals, from initial infection through chronic disease. Progressive and non-progressive HIV infection models show the cytokine milieu differs in terms of production and responsiveness in these two groups, suggesting an understanding of the role cytokines play during infection is necessary for directing the immune response toward viral control. This review will cover cytokine induction and dysfunction during HIV pathogenesis, with a focus on the interplay between cytokines and transcription factors, T cell activation, and exhaustion. We highlight cytokines that have either vaccine adjuvant or therapeutic potential and discuss the need to identify key factors required for prevention of progression, clearance of infection, or protection from acquisition.
许多研究已经描述了从初始感染到慢性疾病期间在人类免疫缺陷病毒 (HIV) 感染者中观察到的细胞因子调节。进展性和非进展性 HIV 感染模型表明，这两组在细胞因子环境方面的产生和反应性存在差异，这表明了解细胞因子在感染过程中所起的作用对于指导免疫反应以实现病毒控制是必要的。本综述将涵盖 HIV 发病机制过程中的细胞因子诱导和功能障碍，重点讨论细胞因子与转录因子、T 细胞激活和耗竭之间的相互作用。我们强调了具有疫苗佐剂或治疗潜力的细胞因子，并讨论了需要确定预防进展、清除感染或防止获得所需的关键因素。
