多酚化合物对甲型流感病毒复制的影响及其作用机制的定义。
Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.
机构信息
Istituto Pasteur Cenci Bolognetti - Dip. Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
出版信息
Bioorg Med Chem. 2012 Aug 15;20(16):5046-52. doi: 10.1016/j.bmc.2012.05.062. Epub 2012 Jun 4.
A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.
合成了一组多酚化合物，并检测了它们抑制甲型流感病毒复制的能力。其中一部分化合物显示出低毒性。在此子集中，最好的化合物是 4 和 6g，它们以剂量依赖的方式抑制病毒复制。这些分子的抗病毒活性是由于它们干扰了病毒复制所利用的细胞内途径：（1）控制病毒核糖核蛋白复合物核质转运的 MAP 激酶；（2）参与病毒血凝素蛋白成熟的氧化还原敏感途径。
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