Mychaluk Johanna, Baron Marc, Fondrinier Eric, Laberge Sophie, Gondry Jean, Fauvet Raffaèle
CHU d'Amiens, centre de gynécologie obstétrique, France.
Bull Cancer. 2012 Jul-Aug;99(7-8):771-8. doi: 10.1684/bdc.2012.1614.
From the analysis of our series and a review of the literature, we have done a summary of the clinicopathologic patterns and treatment of squamous cell carcinoma of the breast. It usually presents as a large palpable mass in a woman over 50 years old. There are no specific iconographic features, but a relative frequency of presentation as abscess or cyst. The overall and disease-free survivals are worse than other histological types of breast cancer. These neoplasms have a basal-like and triple negative profile and they respond poorly to standard treatment of breast carcinomas. They are usually treated by radical surgery. Optimal chemotherapy regimens is not yet determined and platin based chemotherapy could offer an effective alternative as the developpement of specific targeted therapies (anti Her1) could do.
通过对我们系列病例的分析以及文献回顾，我们对乳腺鳞状细胞癌的临床病理模式和治疗方法进行了总结。它通常表现为一名50岁以上女性可触及的大肿块。没有特定的影像学特征，但相对常见表现为脓肿或囊肿。其总生存率和无病生存率低于其他组织学类型的乳腺癌。这些肿瘤具有基底样和三阴性特征，对乳腺癌的标准治疗反应不佳。它们通常通过根治性手术治疗。最佳化疗方案尚未确定，基于铂类的化疗可能是一种有效的替代方案，因为特定靶向治疗（抗Her1）的发展也可能如此。
