Haboub Fadwa, Zouiten Othmane, El Fadli Mohamed, Afani Leila, Belbaraka Rhizlane
Medical Oncology, Mohammed VI University Hospital of Marrakech, Marrakech, MAR.
Medical Oncology, Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University, Marrakech, MAR.
Cureus. 2025 Aug 5;17(8):e89443. doi: 10.7759/cureus.89443. eCollection 2025 Aug.
Sebaceous carcinoma of the breast is a rare and poorly understood variant of metaplastic breast carcinoma. Its histogenesis, clinical behavior, and optimal management remain unclear due to the limited number of reported cases. We report the case of a 78-year-old woman presenting with a six-month history of a right axillary mass and inflammatory changes in the right breast. Clinical and radiologic assessments indicated an advanced-stage lesion. Histological analysis from a core needle biopsy revealed solid nests and tubules with sebaceous differentiation. Immunohistochemistry confirmed a triple-negative profile, with high proliferative activity. The patient received neoadjuvant chemotherapy without clinical improvement. Disease progression was noted despite a switch to a platinum-based regimen, followed by further deterioration after additional treatment. The patient was eventually lost to follow-up. This case highlights the aggressive nature and treatment resistance of this carcinoma and underscores the need for further investigation to better define its characteristics and guide therapeutic strategies.
乳腺皮脂腺癌是一种罕见且了解甚少的化生性乳腺癌变体。由于报告的病例数量有限，其组织发生、临床行为及最佳治疗方案仍不明确。我们报告一例78岁女性，有右腋窝肿块6个月病史及右乳腺炎症改变。临床和影像学评估显示为晚期病变。粗针活检的组织学分析显示有皮脂腺分化的实性巢状和小管状结构。免疫组化证实为三阴性特征，增殖活性高。患者接受新辅助化疗后病情无改善。尽管改用铂类方案，病情仍进展，后续治疗后进一步恶化。该患者最终失访。本病例突出了这种癌症的侵袭性和治疗抵抗性，并强调需要进一步研究以更好地明确其特征并指导治疗策略。
