Tan Jackie, Pretorius Casper Francois, Flanagan Paul Vincent, Pais Antonio
General Sugery Department, Mackay Base Hospital, Mackay, Australia.
BMJ Case Rep. 2012 Jun 28;2012:bcr1120115270. doi: 10.1136/bcr.11.2011.5270.
Rosuvastatin (Crestor, AstraZeneca) is a commonly used drug for managing hypercholesterolaemia. It is a very safe medication with mostly acceptable side effects. Rare but serious side effects are not well known. A 64-year-old woman presented with bloody diarrhoea after starting rosuvastatin for hypercholesterolaemia. Stool microscopy and culture ruled out infective causes. Abdominal CT scan revealed normal calibre celiac axis and superior mesenteric artery. Colonoscopic biopsy revealed ischaemic colitis as the final histological diagnosis. The patient is in complete remission after ceasing the medication. Rosuvastatin causing ischaemic colitis should be considered a rare but serious adverse drug reaction.
瑞舒伐他汀（可定，阿斯利康公司）是一种常用于治疗高胆固醇血症的药物。它是一种非常安全的药物，大多数副作用都是可以接受的。罕见但严重的副作用并不为人熟知。一名64岁女性在开始服用瑞舒伐他汀治疗高胆固醇血症后出现血性腹泻。粪便显微镜检查和培养排除了感染性病因。腹部CT扫描显示腹腔干和肠系膜上动脉管径正常。结肠镜活检最终组织学诊断为缺血性结肠炎。停药后患者完全缓解。应将瑞舒伐他汀引起的缺血性结肠炎视为一种罕见但严重的药物不良反应。
