Roliński Z, Wlaź P
Department of Pharmacology, Institute of Physiological Sciences, School of Agriculture, Lublin, Poland.
Pol J Pharmacol. 1993 Jan-Feb;45(1):43-9.
In this study the authors have evaluated the effects of common antiepileptic drugs given alone or in combinations with baclofen on seizures evoked by intravenous flunarizine in rabbits. The abolition of clonic and clonic-tonic convulsions was taken as the end point. Baclofen was able to inhibit convulsions only in a relatively high dose (5 mg/kg). Diazepam (1.5 mg/kg) and clonazepam (2 mg/kg) completely abolished clonic seizures. Valproate (20 mg/kg) inhibited clonic seizures and remained without effect on tonic convulsions. Other antiepileptics such as carbamazepine and acetazolamide were found inactive in this respect. Moreover, combinations of acetazolamide (100 mg/kg) and carbamazepine (50 mg/kg) with baclofen (2 mg/kg) had no anticonvulsant effect. Thus, mainly GABA modulatory drugs reveal significant action against flunarizine-induced seizures.
在本研究中，作者评估了单独使用或与巴氯芬联合使用的常见抗癫痫药物对兔静脉注射氟桂利嗪诱发的癫痫发作的影响。以阵挛性和阵挛 - 强直性惊厥的消除作为终点。巴氯芬仅在相对高剂量（5mg/kg）时能够抑制惊厥。地西泮（1.5mg/kg）和氯硝西泮（2mg/kg）完全消除了阵挛性发作。丙戊酸盐（20mg/kg）抑制阵挛性发作，对强直性惊厥无作用。发现其他抗癫痫药如卡马西平和乙酰唑胺在这方面无活性。此外，乙酰唑胺（100mg/kg）和卡马西平（50mg/kg）与巴氯芬（2mg/kg）的联合使用没有抗惊厥作用。因此，主要是γ-氨基丁酸（GABA）调节药物对氟桂利嗪诱发的癫痫发作显示出显著作用。
