13H-萘并[1',2':7,6][1,4]二氮杂卓并[2,3-b]吡啶的合成与药理性质
Synthesis and pharmacological properties of 13H-naphtho[1',2':7,6] [1,4] diazepino[2,3-b] pyridines.
作者信息
Kaczmarek L, Nantka-Namirski P, Dereń A, Chojnacka-Wójcik E
机构信息
Institute of Organic Chemistry, Polish Academy of Sciences, Warszawa, Poland.
出版信息
Pol J Pharmacol Pharm. 1990 Mar-Apr;42(2):165-75.
The synthesis and properties of 13H-naphtho[1',2':7,6] [1,4] diazepino[2,3-b] pyridines (7a--g) were described. New compounds were studied in rats and in mice in the tests used for preclinical assessment of antidepressant or anxiolytic activity. Compound 7c showed weak antagonism towards the reserpine-induced hypothermia and shortened immobility time in the despair test. None of the tested compounds had an anxiety-relieving action.
描述了13H-萘并[1',2':7,6][1,4]二氮杂卓并[2,3-b]吡啶（7a - g）的合成及其性质。在用于抗抑郁或抗焦虑活性临床前评估的试验中，对新化合物在大鼠和小鼠中进行了研究。化合物7c对利血平诱导的体温过低表现出微弱的拮抗作用，并在绝望试验中缩短了不动时间。所测试的化合物均无缓解焦虑的作用。
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