Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, India.
Am J Chin Med. 2012;40(3):567-80. doi: 10.1142/S0192415X12500437.
Hemidesmus indicus (HI) is used in ancient Indian traditional herbal medicine to treat hepatic and renal disorders. The present study was designed to investigate the protective effect of HI aqueous extract against bromobenzene induced mitochondrial dysfunction in rat kidneys. Rats were administered bromobenzene with or without prior administration of HI or vitamin E. At the end of the experiment animals were sacrificed and kidneys were obtained to study mitochondrial function, oxidative stress parameters and histopathology. Administration of bromobenzene caused significant changes like: decrease in the mitochondrial respiration and P/O ratios, increase in lipid peroxidation and protein oxidation, and decrease in the activities of antioxidant enzymes (catalase, glutathione reductase, glutathione peroxidase and superoxide dismutase) in mitochondria with significant histopathological changes in the kidney. Prior administration of HI extract showed a significant protection against bromobenzene induced changes in the kidney and this effect is attributed to the antioxidant and free radical scavenging potential of the HI. The protection was much better with HI compared to vitamin E.
印度土槿皮（HI）在古印度传统草药医学中被用于治疗肝脏和肾脏疾病。本研究旨在探讨 HI 水提物对溴苯诱发的大鼠肾脏线粒体功能障碍的保护作用。大鼠给予溴苯，并在给予 HI 或维生素 E 之前或之后给予 HI 或维生素 E。实验结束时，处死动物并获取肾脏，以研究线粒体功能、氧化应激参数和组织病理学。溴苯的给药导致了显著的变化，如线粒体呼吸和 P/O 比的降低，脂质过氧化和蛋白质氧化的增加，以及抗氧化酶（过氧化氢酶、谷胱甘肽还原酶、谷胱甘肽过氧化物酶和超氧化物歧化酶）活性的降低，同时肾脏出现明显的组织病理学变化。HI 提取物的预先给予对溴苯引起的肾脏变化表现出显著的保护作用，这种作用归因于 HI 的抗氧化和自由基清除潜力。与维生素 E 相比，HI 的保护作用更好。
