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[结核病患者家庭中遗传标志物的研究]

[Study of genetic markers in families of patients with tuberculosis].

作者信息

Rakhimov A Kh, Pospelov L E

出版信息

Probl Tuberk. 1990(9):7-8.

PMID:2274516
Abstract

The article deals with findings of the study of HLA-genotype influence on tuberculosis susceptibility in 26 families with tuberculosis patients. It was found that sensitivity to tuberculosis in the examined families is associated with HLA-DR2 antigen. Segregation analyses conducted in the families of patients with tuberculosis revealed a correlation between the sensitivity to tuberculosis and inheritance of certain HLA haplotypes from the affected parents to their children with tuberculosis.

摘要

本文探讨了对26个有结核病患者家庭中HLA基因型对结核病易感性影响的研究结果。研究发现,被调查家庭对结核病的易感性与HLA - DR2抗原相关。在结核病患者家庭中进行的分离分析显示,对结核病的易感性与某些HLA单倍型从患病父母遗传给患结核病的子女之间存在关联。

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