Schwarzkopf S B, Olson S C, Coffman J A, Nasrallah H A
Ohio State University, Department of Psychiatry, Columbus 43210.
Psychopharmacol Bull. 1990;26(3):385-91.
Third and lateral ventricular enlargement exists in a subgroup of schizophrenic patients. It is unclear, however, whether these abnormalities consistently coexist in the same patients or represent distinct pathologies. Whether these changes are static or progressive in nature is also unresolved. Third and lateral ventricular volumes (magnetic resonance imaging, total volumes calculated on complete coronal series) were examined in controls (n = 20) and schizophrenic patients (n = 20). Third ventricular, but not lateral ventricular, volume was increased in patients. Ventricular intercorrelations differed significantly between patients and controls. Ventricular measures were more highly correlated in patients than in controls. Age was also significantly more positively correlated with ventricular measures in patients. Results replicate the finding of third ventricular enlargement in some schizophrenic patients. The high correlation between lateral and third ventricular size in schizophrenic patients suggests a pathologic process affecting both structures. Enlargement of both third and lateral ventricles may be more specific to schizophrenic patients than enlargement of either structure alone. The data also indirectly support progression of ventricular enlargement.
部分精神分裂症患者存在第三脑室和侧脑室扩大的情况。然而，尚不清楚这些异常是否始终在同一患者中并存，或者是否代表不同的病理情况。这些变化在本质上是静态的还是渐进性的也尚未得到解决。我们对20名对照组和20名精神分裂症患者进行了第三脑室和侧脑室容积（磁共振成像，根据完整冠状序列计算总体积）的检查。患者的第三脑室容积增加，但侧脑室容积未增加。患者和对照组之间的脑室相互关联存在显著差异。患者脑室测量值之间的相关性高于对照组。年龄与患者脑室测量值的正相关性在患者中也显著更高。研究结果重复了部分精神分裂症患者存在第三脑室扩大的发现。精神分裂症患者侧脑室和第三脑室大小之间的高相关性表明存在影响这两个结构的病理过程。第三脑室和侧脑室同时扩大可能比单独一个结构扩大对精神分裂症患者更具特异性。这些数据也间接支持脑室扩大的进展。
