Weinberger D R, Torrey E F, Neophytides A N, Wyatt R J
Arch Gen Psychiatry. 1979 Jul;36(7):735-9. doi: 10.1001/archpsyc.1979.01780070013001.
To investigate if cerebral ventricular enlargement is associated with chronic schizophrenia, computerized tomography scans from 73 psychiatric patients were compared with 56 asymptomatic volunteers all less than 50 years old. Ventricular size was significantly greater in the subgroup of 58 chronic schizophrenic patients than in the controls. Of the chronic schizophrenic patients, 40% were outside the control range; 53% exceeded 2 SDs of the control mean. Neither duration of illness nor length of hospitalization correlated with ventricular size. The 44 chronic schizophrenic patients who had never been treated with electroshock therapy (EST) had larger ventricles than controls. A group of seven nonchronic schizophrenic patients also had enlarged ventricles; the eight patients who were either schizoaffective or nonschizophrenic did not differ from controls. This study shows that lateral cerebral ventricular enlargement is associated with chronic schizophrenia; it suggests that this is not a result of treatment.
为研究脑室扩大是否与慢性精神分裂症相关，对73名精神科患者和56名年龄均小于50岁的无症状志愿者进行了计算机断层扫描，并对两者进行比较。58名慢性精神分裂症患者亚组的脑室大小显著大于对照组。在慢性精神分裂症患者中，40%超出了对照组范围；53%超过了对照组均值的2个标准差。疾病持续时间和住院时间均与脑室大小无关。44名从未接受过电击治疗（EST）的慢性精神分裂症患者的脑室比对照组更大。一组7名非慢性精神分裂症患者的脑室也扩大；8名患有精神分裂症伴情感障碍或非精神分裂症的患者与对照组无差异。这项研究表明，大脑外侧脑室扩大与慢性精神分裂症相关；提示这并非治疗所致。
