生长激素可增加大鼠结肠的质量、胶原蛋白含量及强度。

Growth hormone increases the mass, the collagenous proteins, and the strength of rat colon.

作者信息

Christensen H, Jørgensen P H, Oxlund H, Laurberg S

机构信息

Dept. of Connective Tissue Biology, University of Aarhus, Denmark.

出版信息

Scand J Gastroenterol. 1990 Nov;25(11):1137-43. doi: 10.3109/00365529008998546.

DOI:10.3109/00365529008998546

PMID:2274736

Abstract

The effect of growth hormone treatment on the left colon was investigated in 4-month-old Wistar rats. The animals were injected with saline (controls) or biosynthetic human growth hormone (b-hGH) in doses of 1.0 and 5.0 mg b-hGH/kg/day for 30 days. The total body weight of the rats injected with 1.0 mg b-hGH/kg/day did not differ from that of the control group, whereas the body weight of the rats injected with 5.0 mg b-hGH/kg/day was increased by 37% compared with the control group. The colonic dry weight per unit length was increased by 57% and 46% by 1.0 mg and 5.0 mg b-hGH/kg/day, respectively. The defatted dry weight was increased by 52% and 44%, respectively. The hydroxyproline content per unit length was increased by 31% and 23%, respectively. Furthermore, the biomechanical strength was increased by the b-hGH injections. No difference between the two b-hGH doses was found in any of the data.

摘要

在4月龄的Wistar大鼠中研究了生长激素治疗对左结肠的影响。给动物注射生理盐水（对照组）或生物合成人生长激素（b-hGH），剂量分别为1.0和5.0 mg b-hGH/kg/天，持续30天。注射1.0 mg b-hGH/kg/天的大鼠总体重与对照组无差异，而注射5.0 mg b-hGH/kg/天的大鼠体重比对照组增加了37%。每单位长度结肠的干重分别因1.0 mg和5.0 mg b-hGH/kg/天增加了57%和46%。脱脂干重分别增加了52%和44%。每单位长度的羟脯氨酸含量分别增加了31%和23%。此外，b-hGH注射增加了生物力学强度。在任何数据中均未发现两种b-hGH剂量之间存在差异。