阿片类药物的非镇痛作用：阿片类药物与骨骼和关节的相互作用。
Non-analgesic effects of opioids: the interaction of opioids with bone and joints.
机构信息
Department of Medical and Surgical Sciences and Biotechnologies, Unit of Anesthesia, Intensive Care and Pain Medicine, SAPIENZA University of Rome, Faculty of Pharmacy and Medicine, Latina, Italy.
出版信息
Curr Pharm Des. 2012;18(37):6005-9. doi: 10.2174/138161212803582487.
Opioid consumption is associated with a wide range of side effects. Potential interference of opioids with bone and joint activity has emerged in the last few years. Opioids increase the risk of fracture, especially in elderly patients. Moreover, opioids interfere with the endocrine system, and their chronic use is a recognized risk factor for osteoporosis. Pathogenetic mechanisms at the basis of the interference of opioids with bones and joints are analysed in this review.
阿片类药物的消耗与广泛的副作用有关。近年来，阿片类药物对骨骼和关节活动的潜在干扰作用已经显现出来。阿片类药物会增加骨折的风险，特别是在老年患者中。此外，阿片类药物会干扰内分泌系统，其长期使用被认为是骨质疏松症的一个危险因素。本文对阿片类药物干扰骨骼和关节的发病机制进行了分析。
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