World Health Organization Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Swedish Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden.
Euro Surveill. 2012 Jun 21;17(25):20200.
We describe the second case in Europe of verified treatment failure of pharyngeal gonorrhoea, caused by an internationally occurring multidrug-resistant gonococcal clone, with recommended first-line ceftriaxone 250 mg in Slovenia. This is of grave concern since ceftriaxone is last remaining option for empirical treatment. Increased awareness of ceftriaxone failures, more frequent test-of-cure, strict adherence to regularly updated treatment guidelines, and thorough verification/falsification of suspected treatment failures are essential globally. New effective treatment options are imperative.
我们在欧洲报告了第二例经证实的咽淋病治疗失败病例，该病例由一种在国际上流行的耐多药淋病球菌克隆引起，而推荐的一线治疗药物是头孢曲松 250 毫克，这在斯洛文尼亚。鉴于头孢曲松是经验性治疗的最后选择，因此这令人深感担忧。全球范围内，提高对头孢曲松治疗失败的认识、更频繁地进行治愈检测、严格遵守定期更新的治疗指南以及彻底验证/否定疑似治疗失败至关重要。急需新的有效治疗选择。
