Zhao Yue, Zhan Qimin
State key laboratory of molecular oncology, Cancer Institute & Hospital of Chinese Academy of Medical Sciences, Peking Union Medical College, Room 6107, No,17 Pan Jia Yuan Nan Li, Chao Yang District, Bei Jing, 100021, China.
Theor Biol Med Model. 2012 Jul 2;9:26. doi: 10.1186/1742-4682-9-26.
Super-macromolecular complexes play many important roles in eukaryotic cells. Classical structural biological studies focus on their complicated molecular structures, physical interactions and biochemical modifications. Recent advances concerning intracellular electric fields generated by cell organelles and super-macromolecular complexes shed new light on the mechanisms that govern the dynamics of mitosis and meiosis. In this review we synthesize this knowledge to provide an integrated theoretical model of these cellular events. We suggest that the electric fields generated by synchronized oscillation of microtubules, centrosomes, and chromatin fibers facilitate several events during mitosis and meiosis, including centrosome trafficking, chromosome congression in mitosis and synapsis between homologous chromosomes in meiosis. These intracellular electric fields are generated under energy excitation through the synchronized electric oscillations of the dipolar structures of microtubules, centrosomes and chromosomes, three of the super-macromolecular complexes within an animal cell.
超大分子复合物在真核细胞中发挥着许多重要作用。经典的结构生物学研究聚焦于它们复杂的分子结构、物理相互作用和生化修饰。细胞器和超大分子复合物产生的细胞内电场的最新进展为有丝分裂和减数分裂动力学的调控机制提供了新的线索。在本综述中，我们整合这些知识以提供这些细胞事件的综合理论模型。我们认为，微管、中心体和染色质纤维的同步振荡产生的电场促进了有丝分裂和减数分裂期间的多个事件，包括中心体运输、有丝分裂中的染色体汇聚以及减数分裂中同源染色体之间的联会。这些细胞内电场是在能量激发下通过动物细胞内三种超大分子复合物微管、中心体和染色体的偶极结构的同步电振荡产生的。
