Yang Xingxing, Li Zhiyuan, Polyakova Tatyana, Dejneka Alexandr, Zablotskii Vitalii, Zhang Xin
High Magnetic Field Laboratory Key Laboratory of High Magnetic Field and Ion Beam Physical Biology Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei China.
Science Island Branch of Graduate School University of Science and Technology of China Hefei China.
FASEB Bioadv. 2020 Mar 7;2(4):254-263. doi: 10.1096/fba.2019-00045. eCollection 2020 Apr.
Interactions between magnetic fields (MFs) and living cells may stimulate a large variety of cellular responses to a MF, while the underlying intracellular mechanisms still remain a great puzzle. On a fundamental level, the MF - cell interaction is affected by the two broken symmetries: (a) left-right (LR) asymmetry of the MF and (b) chirality of DNA molecules carrying electric charges and subjected to the Lorentz force when moving in a MF. Here we report on the chirality-driven effect of static magnetic fields (SMFs) on DNA synthesis. This newly discovered effect reveals how the interplay between two fundamental features of symmetry in living and inanimate nature-DNA chirality and the inherent features of MFs to distinguish the left and right-manifests itself in different DNA synthesis rates in the upward and downward SMFs, consequently resulting in unequal cell proliferation for the two directions of the field. The interplay between DNA chirality and MF LR asymmetry will provide fundamental knowledge for many MF-induced biological phenotypes.
磁场（MFs）与活细胞之间的相互作用可能会刺激细胞对MF产生各种各样的反应，而其潜在的细胞内机制仍然是一个巨大的谜团。从根本层面上讲，MF与细胞的相互作用受到两种破缺对称性的影响：（a）MF的左右（LR）不对称性，以及（b）携带电荷的DNA分子的手性，当DNA分子在MF中移动时会受到洛伦兹力的作用。在此，我们报告静磁场（SMFs）对手性驱动的DNA合成的影响。这一新发现的效应揭示了生物与非生物自然界中两个基本对称特征——DNA手性和MF区分左右的固有特征——之间的相互作用是如何在向上和向下的SMF中以不同的DNA合成速率表现出来的，从而导致细胞在磁场的两个方向上增殖不均等。DNA手性与MF的LR不对称性之间的相互作用将为许多MF诱导的生物学表型提供基础知识。
