Instituto de Biología Molecular y Celular de Rosario-CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario, Argentina.
FEBS J. 2012 Oct;279(19):3529. doi: 10.1111/j.1742-4658.2012.08685.x. Epub 2012 Aug 29.
PDZ domains are very abundant protein interaction domains widespread in nature. A large amount of evidence has underscored the importance of the PDZ interactions in the control of intracellular pathways whose abnormal regulation may lead to the development of several pathologies. This series of minireviews covers different aspects of human PDZ-containing proteins, underlining and discussing new concepts and findings.
PDZ 结构域是自然界中广泛存在的一种非常丰富的蛋白质相互作用结构域。大量证据强调了 PDZ 相互作用在控制细胞内途径中的重要性，这些途径的异常调节可能导致多种病理学的发生。这一系列迷你评论涵盖了人类含有 PDZ 结构域的蛋白质的不同方面，强调和讨论了新概念和新发现。
