International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
FEBS J. 2012 Oct;279(19):3530-3537. doi: 10.1111/j.1742-4658.2012.08709.x. Epub 2012 Aug 29.
The human papillomavirus (HPV) E6 oncoprotein is fundamental to the ability of these viruses to induce human malignancy. A defining characteristic of the HPV E6 oncoproteins found in cancer-causing HPV types is the presence of a PDZ binding motif at their extreme C-terminus. Through this motif, E6 is able to interact with a large number of cellular proteins that contain PDZ domains. Many of these cellular proteins are involved in regulation of processes associated with the control of cell attachment, cell proliferation, cell polarity and cell signaling. How E6 targets multiple proteins containing the same recognition domain is still an open question. In this review, we highlight aspects of E6 function and biology that help to answer this question, and thereby provide insight into the role of these substrates during development of HPV-induced malignancy.
人乳头瘤病毒（HPV）E6 癌蛋白是这些病毒诱导人类恶性肿瘤的能力的基础。致癌 HPV 类型中发现的 HPV E6 癌蛋白的一个特征是在其 C 端末端存在 PDZ 结合基序。通过这个基序，E6 能够与大量含有 PDZ 结构域的细胞蛋白相互作用。这些细胞蛋白中的许多蛋白参与调节与细胞附着、细胞增殖、细胞极性和细胞信号传导相关的过程。E6 如何靶向含有相同识别结构域的多种蛋白仍然是一个悬而未决的问题。在这篇综述中，我们强调了 E6 功能和生物学的各个方面，这些方面有助于回答这个问题，从而深入了解这些底物在 HPV 诱导的恶性肿瘤发展过程中的作用。
