Jiang Xinyuan, Xu Zhiyong, Jiang Sujing, Wang Huan, Xiao Mingshu, Shi Yueli, Wang Kai
Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China.
Cancers (Basel). 2023 Oct 19;15(20):5042. doi: 10.3390/cancers15205042.
PDZ-LIM family proteins (PDLIMs) are a kind of scaffolding proteins that contain PDZ and LIM interaction domains. As protein-protein interacting molecules, PDZ and LIM domains function as scaffolds to bind to a variety of proteins. The PDLIMs are composed of evolutionarily conserved proteins found throughout different species. They can participate in cell signal transduction by mediating the interaction of signal molecules. They are involved in many important physiological processes, such as cell differentiation, proliferation, migration, and the maintenance of cellular structural integrity. Studies have shown that dysregulation of the PDLIMs leads to tumor formation and development. In this paper, we review and integrate the current knowledge on PDLIMs. The structure and function of the PDZ and LIM structural domains and the role of the PDLIMs in tumor development are described.
PDZ-LIM家族蛋白（PDLIMs）是一类含有PDZ和LIM相互作用结构域的支架蛋白。作为蛋白质-蛋白质相互作用分子，PDZ和LIM结构域作为支架发挥作用，可与多种蛋白质结合。PDLIMs由在不同物种中发现的进化保守蛋白组成。它们可以通过介导信号分子的相互作用参与细胞信号转导。它们参与许多重要的生理过程，如细胞分化、增殖、迁移以及细胞结构完整性的维持。研究表明，PDLIMs的失调会导致肿瘤的形成和发展。在本文中，我们回顾并整合了目前关于PDLIMs的知识。描述了PDZ和LIM结构域的结构和功能以及PDLIMs在肿瘤发展中的作用。
