Titovets E P
Biokhimiia. 1979 Aug;44(8):1506-11.
The kinetics of 4-anilino-5-methoxydioxybenzene-1,2 (AMOBQH2) autoxidation in biochemical systems possessing the superoxide dismutase activity were studied. The autoxidation of AMOBQH2 is affected by superoxide dismutase, which is indicative of participation of the superoxide radical in this process. The main kinetic effect of superoxide dismutase consists in a decrease of the effective rate constant for AMOBQH2 autoxidation. Peroxidase releases the superoxide dismutase inhibition of AMOBQH2 autoxidation. The data obtained are discussed in terms of a biochemical mechanism of action of biologically active aminoaromatic derivatives of o-benzoquinone.
研究了具有超氧化物歧化酶活性的生化系统中4-苯胺基-5-甲氧基二羟基苯-1,2（AMOBQH2）自氧化的动力学。超氧化物歧化酶会影响AMOBQH2的自氧化，这表明超氧阴离子参与了该过程。超氧化物歧化酶的主要动力学效应在于降低了AMOBQH2自氧化的有效速率常数。过氧化物酶可消除超氧化物歧化酶对AMOBQH2自氧化的抑制作用。根据邻苯醌生物活性氨基芳族衍生物的生化作用机制对所得数据进行了讨论。
