[前列地尔对顽固性动脉高血压患者升压和降压体液系统的影响]
[The effect of prostenon on the pressor and depressor humoral systems in patients with resistant arterial hypertension].
作者信息
Zeĭnalov F M, Vasil'ev Iu M, Volos B E
出版信息
Ter Arkh. 1990;62(8):67-70.
After ineffective combined drug therapy patients with the resistant patterns of arterial hypertension were given 3 to 5 intravenous injections of prostenon (prostaglandin E2) in the total dose 3-5 mg. Prostenon was noted to produce a lasting hypotensive effect in patients with resistant essential hypertension and parenchymatous renal hypertension. The patients manifested favourable changes in the general clinical symptomatology. The antihypertensive effect of prostenon was related to appreciable activation of depressor humoral factors, with activation of pressor humoral factors being less remarkable.
在联合药物治疗无效后，对具有顽固性高血压模式的患者静脉注射3至5次前列腺素E2（前列地尔），总剂量为3 - 5毫克。结果发现，前列地尔对顽固性原发性高血压和实质性肾性高血压患者产生了持久的降压作用。患者的一般临床症状有明显改善。前列地尔的降压作用与降压性体液因子的显著激活有关，而升压性体液因子的激活则不太明显。
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