Gandzha T I
Vrach Delo. 1990 Aug(8):16-8.
The authors investigated the basal level of pressor and depressor fractions of blood plasma prostaglandins in 92 patients with hypertensive disease (stage II) showing a different plasma renin activity and reaction of the prostaglandin system to acute furosemide loads in 27 patients and 16 practically healthy persons. It was found that the hypertensive patients revealed a prevailing pressor fraction of prostaglandins against the background of unchanged depressor prostaglandins. In the healthy stimulation with the saluretic agent resulted in physiological mobility of the system of prostaglandins manifested in a rapid response of the humoral system directed to limitation of fluid and sodium losses. In hypertensive disease, however, there occurred a sharp reduction of the reactive capacity of the depressor system, its exhaustion and inertness.
作者研究了92例高血压病（Ⅱ期）患者血浆前列腺素升压和降压组分的基础水平，这些患者表现出不同的血浆肾素活性，还研究了27例患者和16例实际健康者前列腺素系统对急性速尿负荷的反应。结果发现，高血压患者在降压前列腺素不变的背景下，显示出前列腺素的升压组分占优势。在健康人群中，使用利尿剂刺激会导致前列腺素系统的生理活性，表现为体液系统迅速做出反应，以限制液体和钠的流失。然而，在高血压病中，降压系统的反应能力急剧下降，出现衰竭和惰性。
