Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia.
Maturitas. 2012 Aug;72(4):311-6. doi: 10.1016/j.maturitas.2012.05.015. Epub 2012 Jun 27.
During the past 50 years, the prevalence of a cluster of chronic, inactivity-related diseases including obesity, insulin resistance and type 2 diabetes mellitus (T2DM), collectively referred to as 'metabolic syndrome' (MetS) has reached global epidemic proportions. Appropriate exercise training is a clinically proven, cost-effective, primary intervention that delays and in many cases prevents the health burdens associated with MetS. Indeed, there is no single intervention with greater efficacy than physical exercise to reduce the risk of virtually all chronic diseases simultaneously. However compliance to National guidelines for physical activity remains low, with "a lack of time" the most frequently cited barrier to exercise participation by adults, irrespective of age, sex and ethnic background. Part of the growing apathy to modify lifestyle habits is that current public health recommendations may be unrealistic and unattainable for the majority of the populace. Hence, there is an urgent need for innovations in exercise prescription that can be incorporated into daily living and induce clinically beneficial health outcomes. Here we focus attention on a novel form of exercise prescription, high-intensity interval training (HIT), and provide evidence that HIT is a time-efficient and well-tolerated therapeutic intervention to improve cardio-metabolic health in a number of pre-clinical and clinical populations.
在过去的 50 年中，包括肥胖、胰岛素抵抗和 2 型糖尿病（T2DM）在内的一系列与不活动相关的慢性疾病的患病率已达到全球流行的程度，这些疾病统称为“代谢综合征”（MetS）。适当的运动训练是一种经过临床验证的、具有成本效益的主要干预措施，它可以延迟甚至在许多情况下预防与 MetS 相关的健康负担。事实上，没有任何单一的干预措施比体育锻炼更能有效地降低几乎所有慢性疾病的风险。然而，人们对遵循国家运动指南的积极性仍然较低，“缺乏时间”是成年人（无论年龄、性别和种族背景如何）参加运动的最常提到的障碍。部分人对改变生活习惯的冷漠态度部分是由于当前的公共卫生建议可能不切实际，大多数人无法实现。因此，迫切需要创新的运动处方，可以融入日常生活中，并带来有益的临床健康结果。在这里，我们关注一种新形式的运动处方，高强度间歇训练（HIT），并提供证据表明，HIT 是一种高效、耐受良好的治疗干预措施，可改善多种临床前和临床人群的心脏代谢健康。
