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[韦克菲尔德事件:12年的不确定性,而自闭症与麻腮风三联疫苗之间并无关联已得到证实]

[Wakefield's affair: 12 years of uncertainty whereas no link between autism and MMR vaccine has been proved].

作者信息

Maisonneuve Hervé, Floret Daniel

机构信息

Faculté de médecine Paris-Sud 11, département de santé publique, d'évaluation et d'information médicale, 94277 Le Kremlin-Bicêtre, France.

出版信息

Presse Med. 2012 Sep;41(9 Pt 1):827-34. doi: 10.1016/j.lpm.2012.03.022. Epub 2012 Jun 28.

Abstract

In 1998, a Lancet paper described 12 cases of children with autism, and having been vaccinated (MMR) in the United Kingdom; medias presented the information to the lay public, stating that a link was possible. In 2004, The Lancet published letters responding to allegations against the paper. Later, it was established that no link existed between MMR and autism; few years and many publications were necessary to conclude to the absence of evidence. In 2010, the General Medical Council published a report against Dr Wakefield, first author of the 1998 paper, and showing that the children hospital records did not contain the evidence; hospital records differed from the published paper; the Lancet retracted the 1998 paper. In 2011, Brian Deer, a journalist, published the complete story in theBMJ: in 1996, Wakefield was approached by lawyers representing an anti-vaccine lobby, and they supported the Wakefield research. Dr Wakefield left England; in 2012 he works in Texas, USA, for anti-vaccine lobbies.

摘要

1998年,《柳叶刀》发表了一篇论文,描述了12例在英国接种过(麻疹、腮腺炎、风疹联合疫苗,即MMR疫苗)的自闭症儿童病例;媒体将这一信息传达给普通大众,称两者之间可能存在关联。2004年,《柳叶刀》发表了针对对该论文指控的回应信件。后来确定MMR疫苗与自闭症之间不存在关联;经过数年及众多出版物之后才得出没有证据证明两者有关联的结论。2010年,英国医学总会发布了一份针对1998年论文第一作者韦克菲尔德医生的报告,表明儿童医院记录中并无相关证据;医院记录与已发表的论文不符;《柳叶刀》撤回了1998年的那篇论文。2011年,记者布赖恩·迪尔在《英国医学杂志》上公布了完整事件:1996年,代表反疫苗游说团体的律师找到了韦克菲尔德,他们为韦克菲尔德的研究提供了支持。韦克菲尔德医生离开了英国;2012年,他在美国得克萨斯州为反疫苗游说团体工作。

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